Journal of Food, Agriculture and Environment




Vol 11, Issue 3&4,2013
Online ISSN: 1459-0263
Print ISSN: 1459-0255


Evaluation of cardioprotective activities of tanshinone IIA and prostaglandin E1


Author(s):

Jiangwei Ma 1,2, Biao Xu 2, Zengyong Qiao 1*, Huajin Liu 1, Sanjun Xiong 1, Wenbo Cheng 1, Hongwei Wang 1

Recieved Date: 2013-06-11, Accepted Date: 2013-10-19

Abstract:

In this study, we investigated the cardioprotective activities of tanshinone IIA and prostaglandin E1. Ischaemia and reperfusion (IR) were induced in rat hearts. Results showed that tanshinone IIA and prostaglandin E1 increased LVSP, +dp/dtmax, -dp/dtmax, and decreased LVEDP in IR + tanshinone IIA (30 µg/kg) group and IR + tanshinone IIA (30 µg/kg) + prostaglandin E1 (30 µg/kg) group rats. In addition, tanshinone IIA and prostaglandin E1 decreased MDA level, and increased GSH, antioxidant exzymes activities in IR + tanshinone IIA (30 µg/kg) group and IR + tanshinone IIA (30 µg/ kg) + prostaglandin E1 (30 µg/kg) group rats. Moreover, combination of tanshinone IIA and prostaglandin E1 played a synergistic effect against myocardium damage induced by IR. It can be concluded that tanshinone IIA and prostaglandin E1 are effective antioxidants that are able to prevent myocardial ischaemia-reperfusion injury. We suggest that combination of tanshinone IIA and prostaglandin E1 may be useful as an adjunct to thrombolytic therapy in the management of reperfusion injury.

Keywords:

Cardioprotective activities, tanshinone IIA, prostaglandin E1, ischemia reperfusion, rat


Journal: Journal of Food, Agriculture and Environment
Year: 2013
Volume: 11
Issue: 3&4
Category: Food and Health
Pages: 135-138


View full PDF
Information:

Note to users

The requested document is freely available only to subscribers/registered users with an online subscription to the Journal of Food, Agriculture & Environment. If you have set up a personal subscription to this title please enter your user name and password. All abstracts are available for free.

Article purchasing

If you like to purchase this specific document such as article, review or this journal issue, contact us. Specify the title of the article or review, issue, number, volume and date of the publication. Software and compilation, Science & Technology, all rights reserved. Your use of this website details or service is governed by terms of use. Authors are invited to check from time to time news or information.


Purchase this Article:   20 Purchase PDF Order Reprints for 15

Share this article :