Journal of Food, Agriculture and Environment




Vol 11, Issue 3&4,2013
Online ISSN: 1459-0263
Print ISSN: 1459-0255


Effect of Ginkgo biloba ethanol extract and prostaglandin E1 on heart function, oxidative stress in diabetic rats


Author(s):

Zengyong Qiao 1,2, Jiangwei Ma 1 *, Huajin Liu 1, Sanjun Xiong 1, Guanghao Ge 1, Yawei Xu 2

Recieved Date: 2013-05-18, Accepted Date: 2013-10-21

Abstract:

In the present study, we report that ingestion of Ginkgo biloba ethanol extract and prostaglandin E1 significantly decreased serum TG, TC, LDL-c levels and increased HDL-c level in diabetic rats. In addition, Ginkgo biloba ethanol extract and prostaglandin E1 treatment significantly decreased LVEDP, and increased LVSP, +dp/dtmax and -dp/dtmax in diabetic rats. At last, Ginkgo biloba-ethanol extract significantly decreased myocardium MDA, NO2/NO3, NOS, iNOS level and increased SOD level in diabetic rats. Combination of Ginkgo biloba ethanol extract and prostaglandin E1 can play a synergistic effect on alleviating myocardium damage in diabetic rats. It can be concluded that Ginkgo biloba ethanol extract and prostaglandin E1 may provide a useful therapeutic option in the reversal of oxidative stress induced cardiac dysfunction in diabetes mellitus.

Keywords:

Diabetes mellitus, coronary heart disease,  Ginkgo biloba ethanol extract, prostaglandin E1, antioxidant


Journal: Journal of Food, Agriculture and Environment
Year: 2013
Volume: 11
Issue: 3&4
Category: Food and Health
Pages: 131-134


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