Journal of Food, Agriculture and Environment

Vol 11, Issue 2,2013
Online ISSN: 1459-0263
Print ISSN: 1459-0255

Preparation, characterization and in vitro drug release studies of curcumin loaded crosslinked starch microspheres 


Minpeng Zhu, Suhong Li *

Recieved Date: 2012-12-12, Accepted Date: 2013-04-20


Curcumin, a dietary polyphenol, has preventive and therapeutic potential against several diseases. Because of the chronic nature of many of these diseases, controlled release dosage forms of curcumin could be of significant clinical value. However, extreme hydrophobicity and instability of curcumin are significant challenges in its formulation development. Recently studies showed that natural biodegradable polymers microspheres used as drug delivery system could enhance therapeutic activity of curcumin. Therefore, the objectives of this study were to synthesis of a microsphere formulation that could control curcumin release over a period and to determine its release mechanism in vitro. Crosslinked starch microspheres (CSMs) were synthesized with soluble starch as a raw material, N,N’-methylene bisacrylamide (MBAA) as a crosslinker, and K2S2O8 as an initiator. The developed microspheres were characterized by optical microscope, Scanning Electron Microscopy (SEM) and Differential Scanning Calorimetry (DSC). Curcumin was loaded into the CSMs by adsorption method. The CSMs showed a narrow size distribution with 85% between 4 to 10 µm and an average diameter of 7.0 ±1.2 µm and showed better drug entrapment (9.61 mg/g drug loading, 48.5% encapsulation efficiency). In vitro release studies were performed in 7.4 pH media to simulate the intestinal conditions. Release data were fitted to different mathematical models to estimate release parameters and to understand the release mechanism. The results showed a controlled curcumin release over a period of 96 h compared to pure curcumin. The results of these studies suggested that CSMs could be a promising controlled release drug delivery for curcumin. 


Starch microsphere, curcumin, controlled release, crosslinked starch, drug loading, encapsulation efficiency, release kinetics, inverse suspension system, crosslinkage, polymer

Journal: Journal of Food, Agriculture and Environment
Year: 2013
Volume: 11
Issue: 2
Category: Food and Health
Pages: 258-262

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