Journal of Food, Agriculture and Environment

Vol 5, Issue 3&4,2007
Online ISSN: 1459-0263
Print ISSN: 1459-0255

Antibiotics production by Streptomyces lavendulae under different cultural conditions


Mohamed Rizk 1*, Tahany Abdel-Rahman 1, Hanaa Metwally 2

Recieved Date: 2007-04-19, Accepted Date: 2007-08-05


Different natural raw materials were investigated for their suitability in production of antibiotics by Streptomyces lavendulae which antagonize C. albicans growth. Fish meal extract was the most favourable for growth and antibiotic production by S. lavendulae. Six antibiotics, ileumycin, mitomycin C, eurymycin, glomecidin, SL-1 pigment and saframycin A, are produced by S. lavendulae depending on the composition of the induction medium. Maximum production of ileumycin and SL-1 pigment was recorded after 5 days incubation, whereas the highest activities of mitomycin C, eurymycin and glomecidin were recorded after 2-4 days. Saframycin A was the strongest antibiotic that caused the highest degree of C. albicans inhibition after 20 hours. Addition of chloramphenicol concentrations of 30 and 45 mg/ml at pH 5.75 increased the production of saframycin A.


Antibiotics, Streptomyces lavendulae, Candida albicans, raw materials, saframycin A

Journal: Journal of Food, Agriculture and Environment
Year: 2007
Volume: 5
Issue: 3&4
Category: Environment
Pages: 412-415

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