Journal of Food, Agriculture and Environment

Pharmaceutical excipients from natural and microbial origin: An updated review

Author(s):

Dada Kodalkar,   Ajit Kulkarni, Birendra Shrivastav

Recieved Date: 2022-01-21, Accepted Date: 2022-03-25

Abstract:

Excipients are ingredients that are added to pharmaceuticals for a variety of reasons, including enhancing manufacturing, patient acceptance, improving stability, managing release, and so on. Excipients are often the most important components of a medicinal agent, with the active ingredient appearing in just trace levels. Excipients were formerly known as inactive components. However, as the current article points out, excipients may affect the absorption, distribution, metabolism, and excretion (ADME) pathways of the co-administered medication, which is crucial information to know when choosing excipients for a novel formulation. This review also contains a summary of the regulatory processes for getting new excipients approved in various regions, as well as a discussion of recent regulatory initiatives, such as excipients for pediatric formulations, giving pharmaceutical scientists something to think about when choosing excipients for a novel therapeutic formulation.

Keywords:

Drug interactions, excipients, pre-formulation, solid dosage form, stability, toxicology

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Journal: Journal of Food, Agriculture and Environment
Year: 2022
Volume: 20
Issue: 2
Category: Food and Health
Pages: 23-29

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