Journal of Food, Agriculture and Environment

Is Caenorhabditis elegans a suitable model for eco-toxicological studies?

Author(s):

Saleh S. Alhewairini

Recieved Date: 2018-07-22, Accepted Date: 2018-09-26

Abstract:

The diverse application of many pesticides in agriculture, as well as for public purposes, has created pollution in our environment. Caenorhabditis elegans is a species of nematode and the most abundant animal in soil. The drive to reduce the use of animals in toxicity testing and to increase its ease and speed has led to an interest in the use of C. elegans as a model organism in toxicology. Several properties and features of C. elegans (its short life cycle, the ease with which it can be cultured, stored and handled in the laboratory, its physiology and its genetics) have qualified C. elegans to be a potentially excellent organism in such toxicological work as genotoxicity, neurotoxicity and neurodegeneration studies, and the environmental assessment of chemical exposure. The sensitivity of C. elegans is sufficient to show the physiological effects of many xenobiotics, and it has the ability to detoxify several xenobiotic compounds. C. elegans has a simple, well understood nervous system. C. elegans can be found in different media (soil and aquatic conditions). Therefore, it can serve in a variety of environmental assessments in different areas. Unfortunately, C. elegans has a few disadvantages as a model organism in toxicological studies; it is small in size and difficult to work on with the available extraction methods and, of course, because it can never exactly reflect mammalian responses. Nevertheless, it has been proposed that C. elegans could be used as a tool in environmental monitoring.

Keywords:

C. elegans, environmental, eco-toxicological, pesticides, nematode

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Journal: Journal of Food, Agriculture and Environment
Year: 2018
Volume: 16
Issue: 3&4
Category: Environment
Pages: 51-55

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