Journal of Food, Agriculture and Environment

Oxidative stress-mediated signaling pathways: A review 

Author(s):

Jie Yin ^{1, 2, 4}, Wenkai Ren ^{2, 4}, Xiaosong Wu ³*, Guan Yang ⁵, Jing Wang ^{2, 4}, Tiejun Li ²*, Jiannan Ding ¹*, Lichuang Cai¹, Dingding Su⁶

Recieved Date: 2013-01-08, Accepted Date: 2013-04-20

Abstract:

Once the cells are challenged by intra- and extracellular environmental stimuli such as nitric oxide, calcium and pathogenic organisms, the oxidative balance between reactive oxygen species (ROS) (such as O₂^·-, H₂O₂, OH·) production and antioxidant defense systems (such as glutathione reductase and catalase) is broken, resulting in accumulation of ROS within cells. ROS is linked with various cellular signaling pathways, including the nuclear factor erythroid 2-related factor 2/Keap1(Nrf2/Keap1), mitogen-activated protein kinases (MAPKs), the nuclear factor kappa B (NF-κB), protein kinase C (PKC), signal transducers and activators of transcription 3 (STAT3) and peroxisome proliferator-activated receptor-γ (PPARγ), which engaged in regulating pro-oxidant genes and antioxidant genes expression, and mediate cells oxidative injury and antioxidant defense system. This article therefore mainly focuses on: 1) the production of ROS; 2) Nrf2/Keap1, MAPKs, NF-κB, PKC, STAT3 and PPARγ activation mechanism by ROS. 

Keywords:

Molecular mechanism, signalling, oxidative stress

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Journal: Journal of Food, Agriculture and Environment
Year: 2013
Volume: 11
Issue: 2
Category: Food and Health
Pages: 132-139

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