Journal of Food, Agriculture and Environment




Vol 11, Issue 2,2013
Online ISSN: 1459-0263
Print ISSN: 1459-0255


Effect of Astragalus membranaceus aqueous extract on oxidative stress in exhausting exercise mice 


Author(s):

Lijuan Mao 1, Ying Zhao 1*, Aijun Niu 2, Huixin Yang 3

Recieved Date: 2013-01-08, Accepted Date: 2013-04-30

Abstract:

Considerable interest has been focused on the Astragalus membranaceus, which has been used as adjunctive therapy in the treatment of colds and influenza, chronic diarrhoea, oedema, abnormal uterine bleeding and diabetes mellitus, and as a cardiotonic agent.  The effect of Astragalus membranaceus aqueous extract (AMAE) on myocardium oxidant injury in exhausting exercise mice was investigated. Products of lipid peroxidation and the activity of enzymes, namely superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, GOT, CK, Na+, K+-ATPase and Ca2+-Mg2+-ATPase in myocardium tissue were assayed. Results showed that levels of blood TC, TG, LDL-c and MDA, and activities of GOT and CK were significantly higher in the exhausting exercise mice compared to normal control animals. Activities of SOD, CAT, GSH-Px, GR, Na+,K+-ATPase and Ca2+-Mg2+- ATPase were significantly lower in the myocardium tissue of exhausting exercise mice compared to normal control animals. The AMAE treatment dose-dependently significantly reversed these adverse biochemical indices to normal in AMAE-treated mice. It can be concluded that AMAE may decrease exhausting exercise-induced oxidative injury in experimental mice. 

Keywords:

Antioxidant, Astragalus membranaceus, exhausing exercise, mice, myocardium


Journal: Journal of Food, Agriculture and Environment
Year: 2013
Volume: 11
Issue: 2
Category: Food and Health
Pages: 18-21


View full PDF
Information:

Note to users

The requested document is freely available only to subscribers/registered users with an online subscription to the Journal of Food, Agriculture & Environment. If you have set up a personal subscription to this title please enter your user name and password. All abstracts are available for free.

Article purchasing

If you like to purchase this specific document such as article, review or this journal issue, contact us. Specify the title of the article or review, issue, number, volume and date of the publication. Software and compilation, Science & Technology, all rights reserved. Your use of this website details or service is governed by terms of use. Authors are invited to check from time to time news or information.


Purchase this Article:   20 Purchase PDF Order Reprints for 15

Share this article :