Journal of Food, Agriculture and Environment




Vol 12, Issue 1,2014
Online ISSN: 1459-0263
Print ISSN: 1459-0255


CDDP affecting immunity function in gastric cancer rats


Author(s):

Pei-Yan Chen 1, Yu-Ju Zheng 2, Hao Lin 3, Jing-Jun Yi 1 *

Recieved Date: 2013-11-13, Accepted Date: 2014-01-18

Abstract:

CDDP is an important antitumour drug. In the study, gastric cancer model studies were performed using wistar rats. Rats were randomly grouped (n=8 per group): normal control, model control, and two CDDP treatment groups. Rats in model control group were intraperitoneally injected with 5 × 106 8GC823 cells per rats. Rats in CDDP treatment groups were intraperitoneally injected with 5 × 106 8GC823 cells per rats and CDDP (30 mg or 45 mg/kg). Results showed that CDDP could enhance serum IgA, IgM, IgG, CD4+ , IL-2, NK levels, decreased CD8+ levels in gastric cancer rats. CDDP could inhibit tumour growth in a dose-dependent manner in gastric cancer rats. It can be concluded that CDDP may enhance immunity function and decrease tumour growth in gastric cancer rats.

Keywords:

CDDP, antitumour, immunity, gastric cancer


Journal: Journal of Food, Agriculture and Environment
Year: 2014
Volume: 12
Issue: 1
Category: Food and Health
Pages: 55-57


View full PDF
Information:

Note to users

The requested document is freely available only to subscribers/registered users with an online subscription to the Journal of Food, Agriculture & Environment. If you have set up a personal subscription to this title please enter your user name and password. All abstracts are available for free.

Article purchasing

If you like to purchase this specific document such as article, review or this journal issue, contact us. Specify the title of the article or review, issue, number, volume and date of the publication. Software and compilation, Science & Technology, all rights reserved. Your use of this website details or service is governed by terms of use. Authors are invited to check from time to time news or information.


Purchase this Article:   20 Purchase PDF Order Reprints for 15

Share this article :