Journal of Food, Agriculture and Environment

CDDP affecting immunity function in gastric cancer rats

Author(s):

Pei-Yan Chen ¹, Yu-Ju Zheng ², Hao Lin ³, Jing-Jun Yi ^{1 *}

Recieved Date: 2013-11-13, Accepted Date: 2014-01-18

Abstract:

CDDP is an important antitumour drug. In the study, gastric cancer model studies were performed using wistar rats. Rats were randomly grouped (n=8 per group): normal control, model control, and two CDDP treatment groups. Rats in model control group were intraperitoneally injected with 5 × 10⁶ 8GC823 cells per rats. Rats in CDDP treatment groups were intraperitoneally injected with 5 × 10⁶ 8GC823 cells per rats and CDDP (30 mg or 45 mg/kg). Results showed that CDDP could enhance serum IgA, IgM, IgG, CD4⁺ , IL-2, NK levels, decreased CD8+ levels in gastric cancer rats. CDDP could inhibit tumour growth in a dose-dependent manner in gastric cancer rats. It can be concluded that CDDP may enhance immunity function and decrease tumour growth in gastric cancer rats.

Keywords:

CDDP, antitumour, immunity, gastric cancer

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Journal: Journal of Food, Agriculture and Environment
Year: 2014
Volume: 12
Issue: 1
Category: Food and Health
Pages: 55-57

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