Journal of Food, Agriculture and Environment

Vol 11, Issue 1,2013
Online ISSN: 1459-0263
Print ISSN: 1459-0255

The evaluation of the leptin implication in postmenopausal osteoporosis


Diana Camelia Bonte 1*, Adrian C. Ilie 1, Radu E. Iacob 2, Rodica Lighezan 1, Ovidiu H. Bonte 3, Daniela Iacob 1, Andrei Anghel 1

Recieved Date: 2012-10-08, Accepted Date: 2013-01-22


Postmenopausal osteoporosis represents one of the major diseases of modern times and it can be considered an important source of morbidity, mortality and social service spread worldwide. The objectives of this study were the identification of the risk factors involved in postmenopausal osteoporosis, the evaluation of the bone mineral metabolism in postmenopausal women not suffering from osteoporosis and in patients suffering from postmenopausal osteoporosis, as well as the evaluation of the leptin (protein hormone produced by adipocytes) implication in postmenopausal osteoporosis. The study included  a control group with 32 postmenopausal women, with bone mass values within normal limits (group 1) and a group of 107 postmenopausal women with osteoporosis (validated by dual energy X-ray absorptiometry DEXA method), without other pathological conditions (group 2). An individual sheet was drawn up for each patient. Each sheet included a general questionnaire (the bone mass index (BMI) was calculated on the basis of the body weight and height), a questionnaire regarding the life style (smoking habits or alcohol consumption), a questionnaire evaluating the daily calcium intake, a questionnaire assessing the physical effort rate, the use of medicines, the evaluation of the estrogenic status). The level of the intact serum parathormone  iPTH, 25-hydroxyvitamin D and serum leptin levels were analysed with the ELISA technique. Calcemia and phosphatemia were evaluated with standard methods. We found significant statistical differences between the control group and the group with osteoporosis patients regarding the menopause age (p<0.05), the menarche age (p = 0.006), the number of births (p<0.001) as well as the height and weight (p = 0.03 and p<0.05, respectively). We didn’t find statistically significant differences regarding the serum i-PTH and 25-hydroxyvitamin D. Moreover, we found a statistically significant positive correlation between the BMD and leptin for both groups (group 1 p = 0.01; group 2 p = 0.05). Postmenopausal osteoporosis is a multifactorial disease, the bone loss rate being influenced by several factors (among which the estrogen deficiency plays an important role). Our results suggest that leptin is involved in the regulation of bone mass and bone turnover, having a protective effect against the bone mass loss. 


Osteoporosis, postmenopause, leptin, bone mineral density, bone mass index

Journal: Journal of Food, Agriculture and Environment
Year: 2013
Volume: 11
Issue: 1
Category: Food and Health
Pages: 244-245

Full text for Subscribers

Note to users

The requested document is freely available only to subscribers/registered users with an online subscription to the Journal of Food, Agriculture & Environment. If you have set up a personal subscription to this title please enter your user name and password. All abstracts are available for free.

Article purchasing

If you like to purchase this specific document such as article, review or this journal issue, contact us. Specify the title of the article or review, issue, number, volume and date of the publication. Software and compilation, Science & Technology, all rights reserved. Your use of this website details or service is governed by terms of use. Authors are invited to check from time to time news or information.

Purchase this Article:   20 Purchase PDF Order Reprints for 15

Share this article :