Journal of Food, Agriculture and Environment




Vol 8, Issue 3&4,2010
Online ISSN: 1459-0263
Print ISSN: 1459-0255


Glutamine and animal immune function


Author(s):

Fungui Yin , Weiming Jiang 2§ , Shu Guan 3, Zhizhong Pan 2, Xiuli Chen 2, Xiaohang Chen 2*

Recieved Date: 2010-08-04, Accepted Date: 2010-11-11

Abstract:

This review will attempt to summarize literatures of the relationship between glutamine (Gln) and the host’s immune function. It will expatiate the connotation of Gln as a “nutritional drug” with many important biochemical roles. The clinical recommendations with regard to patients and experimental animals may benefit from different supplying route of Gln. Scientific studies indicate that Gln, traditionally considered a nonessential amino acid, now is considered “conditionally essential” after critical illness, stress and injury. States of illness or injury can lead to a significant decrease in plasma levels of Gln and when this decrease is severe, it has been correlated with increased mortality. Researches have demonstrated numerous benefits of gln in experimental models of critical illness, burn and cardiac injury. The mechanism of these protective effects includes attenuated pro-inflammatory cytokine expression, improved gut barrier function, enhanced ability to mount a stress response, improved immune cell function and decreased mortality. Clinical trials of gln supplementation in critical illness, surgical stress and cancer have shown benefit with regard to mortality, length of stay and infectious morbidity. However, literatures demonstrating a lack of benefit with Gln supplementation in some patients have been presented as well. No evidence of harm has been observed in studies conducted to reported literatures; thus, further clinical trials using Gln as a pharmacological supplement to “nutritional drug” are warranted.

Keywords:

Glutamine, immune function, immune cells, cytokines


Journal: Journal of Food, Agriculture and Environment
Year: 2010
Volume: 8
Issue: 3&4
Category: Food and Health
Pages: 135-141


View full PDF
Information:

Note to users

The requested document is freely available only to subscribers/registered users with an online subscription to the Journal of Food, Agriculture & Environment. If you have set up a personal subscription to this title please enter your user name and password. All abstracts are available for free.

Article purchasing

If you like to purchase this specific document such as article, review or this journal issue, contact us. Specify the title of the article or review, issue, number, volume and date of the publication. Software and compilation, Science & Technology, all rights reserved. Your use of this website details or service is governed by terms of use. Authors are invited to check from time to time news or information.


Purchase this Article:   20 Purchase PDF Order Reprints for 15

Share this article :