Journal of Food, Agriculture and Environment

Percutaneous absorption of piroxicam: In vitro release and percutaneous absorption from different concentration gels

Author(s):

Rym Ben Mustapha ^1*, Christine Lafforgue ¹, Nadia Fenina ²

Recieved Date: 2010-07-05, Accepted Date: 2010-10-29

Abstract:

The study of molecules skin penetration is very interesting in the field of the pharmaceutical and cosmetic industry and in toxicology. Various studies have considered the impact of different physicchemical drug characteristics, skin thickness, or formulation on the transition from the skin surface to underlying tissues or to the systemic circulation, however, the influence of the drug concentration on the permeation flux of molecules was rarely raised. Our research aims at finding out the influence of the drug concentration in a formulation. For this purpose, three same base gels were used at 1, 3 and 5% of piroxicam to evaluate the effect of concentration on in vitro release through synthetic membrane and ex vivo permeation through human skin of piroxicam using diffusion Franz^TM cells. It is immediately apparent the diffusion through epidermal tissue is significantly slower than through the synthetic membrane which recorded an increase of the flux jointly to the increasing concentration on piroxicam. It was seen, that contrary to the results of in vitro studies, the percutaneous absorption of piroxicam revealed to be not concentration-dependant. Among all the different concentrations of piroxicam gel examined, gel 1% applied at 5 mg/cm² showed the highest permeability coefficient and also the best flux characteristics across human skin.

Keywords:

Absorption rate, diffusion coefficient, Franz ^TM diffusion cells, percutaneous absorption, permeation flow

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Journal: Journal of Food, Agriculture and Environment
Year: 2010
Volume: 8
Issue: 3&4
Category: Food and Health
Pages: 90-95

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