Journal of Food, Agriculture and Environment

Effect of soybean oligosaccharides on immunity and TLR2-NF-κB signal pathway response for weanling pigs

Author(s):

Ruan Zheng ^1#*, Lingyuan Yang ^2#, Xiao-li Zhou ^1#, Changqing Zhu ^3#*, Xu-gang Shu ^1,4, Xin Wu ¹, Hua Li ⁵, Ling Wang ⁵, Jiang Bo ¹

Recieved Date: 2011-08-16, Accepted Date: 2012-01-08

Abstract:

Weaning body leads to intestinal immunological stress and decreases nutrient digestion, absorption and metabolism1-5. We tried to modulate immunological stress with oligosaccharide and elucidate the signal pathway. This study was conducted to investigate the effects of SBOS on plasma concentration of immunoglobulin and interleukin and TLR2–NF-kB signal pathway in weanling mini-piglets. Twelve piglets weaned at 21 day of age were randomly assigned into 0 or 0.5 g/kg of SBOS-supplemented group (6 piglets per group), respectively. At the end of a 14-day feeding period, concentrations of IgG, IgM and IL-2 in plasma and mRNA expression levels of TLR2, MyD88 and NF-kB p65 were measured. Results showed that the SBOS supplementation increased concentrations of immunoglobulins IgG (P<0.05) and IgM (P>0.05) in plasma, as well as cytokines (IL-2) (P<0.05), when compared with the control group; the expression level of TLR2 and MyD88 in the spleen, and of NF-kB p65 and MyD88 in the colon of the piglets fed SBOS-supplemented diet were lower (P<0.05), while NF-kBp65 in the spleen and TLR2 in the colon had no significant difference in comparison with the control group. We conclude that SBOS influences intestinal and spleen immunity by TLR2—NF-kB signal pathway in weanling pigs.

Keywords:

Soybean oligosaccharides, Toll-like receptor 2, nuclear factor-kappa B, immune response, signal pathway

---

Journal: Journal of Food, Agriculture and Environment
Year: 2012
Volume: 10
Issue: 1
Category: Agriculture
Pages: 273-279

---

Full text for Subscribers

---

Information:

Note to users

The requested document is freely available only to subscribers/registered users with an online subscription to the Journal of Food, Agriculture & Environment. If you have set up a personal subscription to this title please enter your user name and password. All abstracts are available for free.

Article purchasing

If you like to purchase this specific document such as article, review or this journal issue, contact us. Specify the title of the article or review, issue, number, volume and date of the publication. Software and compilation, Science & Technology, all rights reserved. Your use of this website details or service is governed by terms of use. Authors are invited to check from time to time news or information.

---

Purchase this Article:   20 Purchase PDF Order Reprints for 15

---

Share this article :