Journal of Food, Agriculture and Environment

Dietary supplementation with high-dose Bacillus subtilis or Lactobacillus reuteri modulates cellular and humoral immunities and improves performance in weaned piglets

Author(s):

Sheng-Ping Wang ^1#, Lingyuan Yang ^2#, Xiang-Shan Tang ¹, Li-Chuang Cai ³, Gang Liu ¹, Xiang-Feng Kong ¹, François Blachier ⁴, Yu-Long Yin ^1*

Recieved Date: 2011-01-08, Accepted Date: 2011-04-07

Abstract:

Bacilli and Lactobacilli, especially high doses of them are often used as probiotics in piglets. The present study aimed to determine the effects of supplementing a piglet diet with high-dose Bacillus subtilis M-1 and Lactobacillus reuteri X-1. A total of 32 piglets with an initial body weight of 5.8±0.10 kg were weaned at 21 d of age and randomly allocated into one of four groups with eight replications of one pig: Group 1, assay diet supplemented with Bacillus subtilis M-1 (10¹¹ cfu kg^-1); Group 2, assay diet supplemented with Lactobacillus reuteri X-1 (10¹¹ cfu kg^-1); Group 3, assay diet supplemented with a combination of Bacillus subtilis M-1 and Lactobacillus reuteri X-1 (0.5×10¹¹ cfu kg^-1, respectively); control group, assay diet without bacterial supplement. Compared with the other groups, Group 2 showed an increase in feed intake (>0.05) and the highest ADG (<0.05), while Group 1 showed the best dry matter intake: gain ratio (<0.05). However, the three treatment groups (Group 1-3) all showed significant decreases in serum IgG and IgM concentrations (P<0.05). Serum TNF-α, IL-6 and NO levels in Group 3 were decreased (<0.05) compared to those in the control group. Serum DAO and D-lactate concentrations were increased in all of the treatment groups (<0.05), compared to those in the control group. These findings show that the addition of high-dose Bacillus subtilis M-1 or Lactobacillus reuteri X-1 to the diet improved growth performance but impaired immunity in weaned piglets.

Keywords:

Bacillus subtilis, Lactobacillus reuteri, high dose, piglet, growth performance, immunity

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Journal: Journal of Food, Agriculture and Environment
Year: 2011
Volume: 9
Issue: 2
Category: Agriculture
Pages: 181-187

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